Active Studies

Study of Women’s Health Across the Nation V

Originating Department: University of Pittsburgh
Principal Investigator Coordinating Center: Maria Brooks, PhD

Principal Investigator Pittsburgh Site: Karen Matthews, PhD
EDC Project Coordinator: Emma Barinas-Mitchell, PhD

SWAN V represents the competitive renewal of the ongoing multi-center, multi-ethnic longitudinal cohort study of the menopausal transition. The URL will be the training and reading site for carotid IMT measurements for four sites.


 Long Life Family Study (LLFS)

Originating Department: University of Pittsburgh
Principal Investigator: Anne Newman, MD, MPH

URL Co-Investigator: Emma Barinas-Mitchell, PhD

The LLFS is a multi-centered proband study evaluating successful aging in an elderly cohort. Vascular aging will be assessed by carotid ultrasound to assess vascular structural changes. The URL will function as the carotid ultrasound training and reading center for three U.S. sites and the Denmark site.


Resistance and Cardiorespiratory Time-matched Exercise in Youth: A Randomized Clinical Trial (RCT:RCT)

Originating Department: Children’s Hospital of Pittsburgh
Principal Investigator: SoJung Lee, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This is an exercise intervention to examine the effect of aerobic exercise, resistance exercise and standard care control (no exercise) on traditional and non-traditional risk factors for CVD and subclinical vascular changes in overweight youth.


A Phase I/II Pilot Study of Dipyridamole as a Modulator of Immune Activation and Systemic Inflammation in HIV-1-Infected Subjects on Antiretroviral Therapy (DIPY)

Originating Department: University of Pittsburgh Medical Center (UPMC)
Principal Investigator: Sharon Riddler
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This is a Phase I/II, randomized, double blind, two-arm, partial cross-over, single-site, pilot study evaluating the effect of oral dipyridamole (DP) on immune activation and inflammation in HIV-1-infected, ART-treated subjects with HIV-1 RNA less than 50 copies/mL and CD4+ cell counts less than or equal to 500/mm3.


A Novel Risk Factor for Cardiovascular Disease: The Insomnia-Short Sleep Phenotype (KINETICS)

Originating Department: University of Pittsburgh
Principal Investigator: Christopher Kline, PhD

URL Co-Investigator: Emma Barinas-Mitchell, PhD

This is a case control study based on a K23 award to determine if insomnia or short sleep duration is associated with subclinical cardiovascular disease. The outcome measures are HOMA-based insulin resistance and brachial artery flow-mediated dilation with the hypothesis that those with insomnia and short sleep duration will exhibit lower insulin sensitivity and lower FMD. This study is partially funded by the URL.


Neurological Pathways Linking Stress to Atherosclerosis (PIP)

Originating Department: University of Pittsburgh
Principal Investigator: Peter Gianaros, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This study tests the central hypothesis that exaggerated blood pressure reactivity to psychological stress and greater preclinical carotid atherosclerosis are commonly associated with stress-induces hyperactivity in a network of brain systems that both process psychological stressors and regulate autonomic, neuroendocrine, and cardiovascular activity. This is the second visit of these participants.


 Sleep, Circadian Rhythms & Cardiometabolic Risk in Retired Shift Workers (SIR)

Originating Department: University of Pittsburgh
Principal Investigator: Daniel Buysse, MD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

The SIR study is being conducted to see if a past history of shift work (working at night on a permanent or rotating basis) has any long-term effect on a person’s sleep patterns, and daily rhythms in physiology (circadian rhythms), as well as on their health and well-being Poor sleep health can increase the risk of health issues such as depression, cognitive impairment, cardiovascular disease and diabetes. The URL performs Carotid Intima-Media Thickness measures, as well as Brachial Artery flow mediated dilatation FMD to assess cardiovascular risk.


In Vivo PIB PET Amyloid Imaging: Normals, MCI, and Dementia Program Project Grant Clinical Core III, Vascular Studies (PPG III)

Originating Department: University of Pittsburgh
Principal Investigator: Beth Snitz, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This Program Project Grant (PPG) Clinical Core III will perform vascular tests to assess overall vascular health. The research is being done to determine why a person with a certain amount of protein in their brain show no symptoms of memory loss, and another person with similar amounts may show more sever symptoms. The particular focus is the possibility that subtle deficiencies in the vascular system (blood supply) of the brain can determine whether a person will show memory symptoms or not. The URL performs ABI’s and IMT measures to assess the person’s vascular system.


Menopausal Vasomotor Symptoms and Brain Aging in Women (MS Brain)

Originating Department: University of Pittsburgh
Principal Investigator: Rebecca C. Thurston, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This study is designed to compare brain structure, brain function, and cognition in women with and without hot flashes. The URL performs both carotid IMT and Pulse Wave Velocity measure to assess arterial stiffness and cardiovascular risk.


Pediatric Depression and Subsiquent Cardiac Risk Factors: A Longitudinal Study (HuCardio)

Originating Department: Semmelweis University Budapest, Hungary
Principal Investigator: Maria Kovacs, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

The URL is the overseeing and coordinating site for the Pulse Wave Velocity measures acquired by 3 different sites in Hungary. The URL is responsible for training and quality control of the Hungarian techs.


Tobago Cardiovascular Study (TCVS)

Originating Department: University of Pittsburgh
Principal Investigator: Allison Kuipers, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

The URL is the training, quality control, and reading center for TCVS.


Mechanism Underlying the impact of Stress and Experiences on Women’s Health (M.U.S.E. Women’s Health Study)

Originating Department: Emory University
Principal Investigator: Tene T. Lewis, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

The purpose of the MUSE Study  is to understand how thoughts, feelings, and experiences affect blood pressure throughout the day and night. It is also interested in determining how thoughts, feelings, and experiences influence changes in the blood vessels of healthy African-American women. It wants to learn more about the factors that contribute to early heart disease and stroke in African-American women. The URL is responsible for reading and quality control for the MUSE Study.


Social Stressors and Atherosclerosis in African-American Women with Lupus (VISTA)

Originating Department: Emory University
Principal Investigator: Tene T. Lewis, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

The purpose of this study is to understand how thoughts, feelings, and experiences affect people who have systemic lupus erythematosus (SLE) and compare it to those who do not have SLE. We are also interested in determining how thoughts, feelings and experiences influence changes in blood vessels of healthy African American women.