Active Studies

Study of Women’s Health Across the Nation V

Originating Department: University of Pittsburgh
Principal Investigator Coordinating Center: Maria Brooks, PhD

Principal Investigator Pittsburgh Site: Karen Matthews, PhD
EDC Project Coordinator: Emma Barinas-Mitchell, PhD

SWAN V represents the competitive renewal of the ongoing multi-center, multi-ethnic longitudinal cohort study of the menopausal transition. The URL will be the training and reading site for carotid IMT measurements for four sites.


Microvascular endothelial dysfunction and atherosclerosis following vascular-mediated preterm birth (WISH 2015)

Originating Department: University of Pittsburgh Medical Center (UPMC)
Principal Investigator: Janet Catov, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

The purpose of this research study is to enroll women who participated in the Women and Infant Study of Healthy Hearts (WISH) to review any changes in hardening of the arteries and/or plaque in the veins and arteries. The results of these tests will help researchers understand changes to blood vessels and their functions as well as the relationship between cardiovascular disease in women with and without pre-term birth, or women who have their babies early.


Maternal Vascular Adaption to Healthy Pregnancy. (MVP2)

Originating Department: University of Pittsburgh
Principle Investigator: Mansi Patel
Co-Investigators: Emma Barinas-Mitchell, PhD; Mindy L. Columbus, MS, MPH

(Maternal Vascular Adaption to Healthy Pregnancy) The purpose of this study is to understand how measures taken in the common carotid arteries can be used to follow the vascular adaptation to pregnancy and to determine the degree to which arteries stiffen in response to this physiological challenge. This is a follow-up visit of participants in the MVP study.


Long Life Family Study (LLFS)

Originating Department: University of Pittsburgh
Principal Investigator: Anne Newman, MD, MPH

URL Co-Investigator: Emma Barinas-Mitchell, PhD

The LLFS is a multi-centered proband study evaluating successful aging in an elderly cohort. Vascular aging will be assessed by carotid ultrasound to assess vascular structural changes. The URL will function as the carotid ultrasound training and reading center for three U.S. sites and the Denmark site.


Resistance and Cardiorespiratory Time-matched Exercise in Youth: A Randomized Clinical Trial (RCT:RCT)

Originating Department: Children’s Hospital of Pittsburgh
Principal Investigator: SoJung Lee, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This is an exercise intervention to examine the effect of aerobic exercise, resistance exercise and standard care control (no exercise) on traditional and non-traditional risk factors for CVD and subclinical vascular changes in overweight youth.


THS Ectopic Fat. T2DM, Coronary Artery Calcification and Ectopic Fat Depots in African Men

Originating Department: University of Pittsburgh
Principal Investigator: Iva Moljkovic, MD, PhD

URL Co-Investigator: Emma Barinas-Mitchell, PhD

The THS Ectopic Fat study is an ancillary study of the Tobago Health Study (THS) to determine the association of ectopic fat (muscle, liver, abdominal and pericardial) with coronary artery calcification in African American men at high risk for type 2 diabetes in the Tobago Health Study. Carotid IMT and pulse wave velocity will also be assessed as additional measures of subclinical vascular disease. This work is partially funded by the URL including training for pulse wave velocity and IMT.


Effect of Reducing Inflammation with Low Dose Methotrexate on Inflammatory Markers and Endothelial Function in Treated and Suppressed HIV Infection (A5314)

Originating Department: University of Pittsburgh Medical Center (UPMC)
Principal Investigator: Sharon Riddler

URL Co-Investigator: Emma Barinas-Mitchell, PhD

A5314 is a phase II, randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of low dose methotrexate (LDMTX) for the treatment of HIV-associated inflammation.


A Phase I/II Pilot Study of Dipyridamole as a Modulator of Immune Activation and Systemic Inflammation in HIV-1-Infected Subjects on Antiretroviral Therapy (DIPY)

Originating Department: University of Pittsburgh Medical Center (UPMC)
Principal Investigator: Sharon Riddler
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This is a Phase I/II, randomized, double blind, two-arm, partial cross-over, single-site, pilot study evaluating the effect of oral dipyridamole (DP) on immune activation and inflammation in HIV-1-infected, ART-treated subjects with HIV-1 RNA less than 50 copies/mL and CD4+ cell counts less than or equal to 500/mm3.


A Novel Risk Factor for Cardiovascular Disease: The Insomnia-Short Sleep Phenotype (KINETICS)

Originating Department: University of Pittsburgh
Principal Investigator: Christopher Kline, PhD

URL Co-Investigator: Emma Barinas-Mitchell, PhD

This is a case control study based on a K23 award to determine if insomnia or short sleep duration is associated with subclinical cardiovascular disease. The outcome measures are HOMA-based insulin resistance and brachial artery flow-mediated dilation with the hypothesis that those with insomnia and short sleep duration will exhibit lower insulin sensitivity and lower FMD. This study is partially funded by the URL.


Femoral Atherosclerosis in Functional Status and CVD Events (FEMA)

Originating Department: University of Pittsburgh
Principal Investigator: Christina Wassel, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This studies an NHLBI funded study to examine the role of atherosclerosis in the femoral artery and inflammation as a predictor of functional status and CVD morbidity/mortality in the San Diego Population study. The URL has developed a protocol for reading the femoral ultrasound images and is the reading center.


Mechanisms Linking Hot Flashes to Cardiovascular Risk (MS Heart)

Originating Department: University of Pittsburgh
Principal Investigator: Rebecca C. Thurston, Ph.D
URL Co-Investigator: Emma Barinas-Mitchell, PhD

Based on preliminary data collected in the URL, Dr. Thurston was funded in 2011 an R01 to assess mechanisms for the link between hot flashes, CVD risk factors and subclinical CVD changes in menopausal women. This grant was funded August 2011 and URL clinic visits, which include brachial artery reactivity testing, as a measure of endothelial function, and carotid IMT, began January 2012.


Neurological Pathways Linking Stress to Atherosclerosis (PIP)

Originating Department: University of Pittsburgh
Principal Investigator: Peter Gianaros, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This study tests the central hypothesis that exaggerated blood pressure reactivity to psychological stress and greater preclinical carotid atherosclerosis are commonly associated with stress-induces hyperactivity in a network of brain systems that both process psychological stressors and regulate autonomic, neuroendocrine, and cardiovascular activity. This is the second visit of these participants.


Long Term Consequences of Systemic Lupus Erythematosus: Vascular and Bone Complications (LUPUS Chicago/SOLVABLE)

Originating Department: Northwestern University
Principal Investigator: Rosalind Ramsey-Goldman, MD, DrPH
URL Co-Investigator: Emma Barinas-Mitchell, PhD

This is an NIH funded study of cardiovascular and bone health endpoints in women with lupus and controls out of Northwestern University. The URL is currently reading second and third follow-up scans and provides ongoing quality control feedback to the ultrasound lab at Northwestern.


Mobility and Independent Living in Elders (MILE)

Originating Department: University of Pittsburgh
Co- Investigator: Dr. PS Reddy
Local Consultants: Anne M. Newman, MD, MPH, Jane A. Cauley, DrPH, Joseph M. Zmuda, PhD, Clareann H. Bunker, PhD
URL Co-Investigator: Emma Barinas-Mitchell, PhD

The MILE study is an observational study originally designed to enroll 500 men and women (250 each) age ?60 in selected geographic regions in the Andhra Pradesh Province of India to establish a longitudinal cohort study in India to define the prevalence, incidence and risk factors for disability and age-related disease in this population. It involves a collaborative effort between the University of Pittsburgh, Share India, the Reach project, and the Mediciti Institute of Medical Sciences (MIMS). The URL has provided carotid training for 3 sonographers. This work is partially funded by the URL.